Glucose and H2O2 dual-sensitive nanogels for enhanced glucose-responsive insulin delivery

• DOI: 10.1039/c9nr01554j
• Publication Date: 2019-04-08T13:04:17Z
• Authors: Chang Li; Xiaoyu Liu; Yong Liu; Fan Huang; Gang Wu; Ying Liu; Zhanzhan Zhang; Yuxun Ding; Juan Lv; Rujiang Ma; Yingli An; Linqi Shi
• Keywords: Nanogel; Glucose oxidase; Phenylboronic acid; Biocompatibility

Diabetes is a chronic metabolic disorder disease characterized by high blood glucose levels and has become one of the most serious threats to human health. In recent decades, number insulin delivery systems, including bulk gels, nanogels, polymeric micelles, have been developed for treatment diabetes. Herein, kind H2O2 dual-responsive nanogel was designed enhanced glucose-responsive delivery. The nanogels composed poly(ethylene glycol) poly(cyclic phenylboronic ester) (glucose dual-sensitive groups) were synthesized one-pot thiol-ene click chemistry approach. displayed release rate could be promoted incorporation oxidase (GOx), which generated at further oxidizes hydrolyzes ester group. characteristics long circulation time, fast response glucose, excellent biocompatibility. Moreover, subcutaneous diabetic mice with insulin/GOx-loaded presented an effective hypoglycemic effect compared that injection or insulin-loaded nanogels. This would promising candidate in future.