Bifunctional squaramide catalyzed stereoselective Mannich reaction of α-azido ketones with isatin-derived ketimines

• DOI: 10.1039/c9ob02208b
• Publication Date: 2019-12-11T15:05:03Z
• Authors: Seda Karahan; Cihangir Tanyeli
• Keywords: Squaramide; Isatin; Mannich reaction; Synthon

Bifunctional squaramide catalyzed asymmetric Mannich reaction of alpha-azido ketones and isatin derived ketiminines were established for the first time with high stereoselectivity. Adducts are valuable synthons optically active heterocycles.