Enantioselective intramolecular C–H amination of aliphatic azides by dual ruthenium and phosphine catalysis

• DOI: 10.1039/c9sc00054b
• Publication Date: 2019-01-29T07:04:52Z
• Authors: Jie Qin; Zijun Zhou; Tianjiao Cui; Marcel Hemming; Eric Meggers
• Keywords: Chemistry; 01 natural sciences; 0104 chemical sciences

By combining a chiral-at-metal ruthenium catalyst with catalytic amounts of tris(p-fluorophenyl)phosphine (both 1 mol%), the challenging catalytic enantioselective ring-closing C(sp3)-H amination of unactivated aliphatic azides has been achieved with high enantioselectivities.