Synthesis of γ-substituted carbonyl compounds from DMSO-mediated oxidation of enynamides: mechanistic insights and carbon- and hetero-functionalizations

• DOI: 10.1039/c9sc03663f
• Publication Date: 2019-08-12T11:10:06Z
• Authors: Quynh H. Nguyen; Nguyen H. Nguyen; Hanbyul Kim; Seunghoon Shin
• Keywords: Carbocation; Heteroatom; Carbon fibers

1,3-Enynamides underwent oxygenative coupling with carbon- and heteroatom nucleophiles high remote selectivity. Kinetic analysis revealed a continuum mechanism between concerted S_N2′′ via carbocation, depending on the used.