Novel four-disulfide insulin analog with high aggregation stability and potency

• DOI: 10.1039/c9sc04555d
• Publication Date: 2019-11-05T16:03:48Z
• Authors: Xiaochun Xiong; Alan Blakely; Prasoona Karra; Michael A. Vanden...; Gabrielle Ghabash; Frank Whitby; Yi Wolf Zhang; Matthew J. Webber; William L. Holland; Christopher P. Hill; Danny Hung-Chieh ...
• Keywords: Insulin analog; Metabolic stability

A novel four-disulfide insulin analog was designed with retained bioactivity and increased fibrillation stability.