Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

• DOI: 10.1039/c9sc04696h
• Publication Date: 2020-01-15T15:44:17Z
• Authors: Jordi Juárez-Jiménez; Arun A. Gupta; Gogulan Karunanithy; Antonia S. J. S. Mey; Charis Georgiou; Harris Ioannidis; Alessio De Simone; Paul N. Barlow; Alison N. Hulme; Malcolm D. Walkin...; Andrew J. Baldwin; Julien Michel
• Keywords: Millisecond; Energy landscape; Cyclophilin

Molecular simulations were used to design large scale loop motions in the enzyme cyclophilin A and NMR biophysical methods employed validate models.