Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy

• DOI: 10.1039/d0bm00172d
• Publication Date: 2020-03-03T10:44:08Z
• Authors: Haishi Qiao; Xingmei Chen; Qiming Wang; Junmei Zhang; Dechun Huang; Enping Chen; Hongliang Qian; Yinan Zhong; Qi Tang; Wei Chen
• Keywords: Oncolytic adenovirus; Boosting; Viral therapy; Cancer Therapy; Virotherapy; Replication

Illustration of pH-degradable microgels (MGs) for the simultaneous encapsulation OA and JQ1 an enhanced oncolytic viral treatment with JQ1-meidated boosting replication PD-L1 suppression.