Efficient synthesis and excellent antimicrobial activity of star-shaped cationic polypeptides with improved biocompatibility

• DOI: 10.1039/d0bm02151b
• Publication Date: 2021-02-11T09:18:00Z
• Authors: Hao Liu; Xu Zhang; Ziyin Zhao; Fangping Yang; Ruizhong Xue; Lichen Yin; Ziyuan Song; Jianjun Cheng; Shifang Luan; Haoyu Tang
• Keywords: Staphylococcus aureus; Anti-Infective Agents; Gram-Negative Bacteria; Escherichia coli; Animals; Gram-Positive Bacteria; Peptides; 01 natural sciences; Anti-Bacterial Agents; 0104 chemical sciences

Star poly(L-lysine) homo- and copolymers with excellent antimicrobial activity and improved biocompatibility can be readily prepared by the combination of ultra-fast ring opening polymerization and efficient side-chain modification.