Three-component ruthenium-catalyzed remote C–H functionalization of 8-aminoquinoline amides

• DOI: 10.1039/d0cc05491g
• Publication Date: 2020-09-16T16:18:59Z
• Authors: Wei-Yu Shi; Ya-Nan Ding; Ce Liu; Nian Zheng; Xue-Ya Gou; Ming Li; Zhe Zhang; Hong-Chao Liu; Zhi-Jie Niu; Yong-Min Liang
• Keywords: Surface Modification; Component (thermodynamics)

Multicomponent reactions can efficiently construct complex molecular structures from simple precursors. Herein, a novel ruthenium-catalyzed three-component highly selective remote C-H functionalization of 8-aminoquinoline amides has been described. The reaction tolerates wide range functional groups, producing arylation/difluoroalkylation products olefins with potential biological activity and pharmaceutical value. Radical scavenging radical clock experiments show that free process is involved H/D exchange experiment suggests the might involve ortho-C-H activation aromatic ring. A possible mechanism proposed.