Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

• DOI: 10.1039/d0cc06349e
• Publication Date: 2020-11-10T12:29:21Z
• Authors: Javier Macías-León; Iris A. Bermejo; Alicia Asín; Ana García-García; Ismael Compañón; Ester Jiménez-Moreno; Helena Coelho; Vincenzo Mangini; Inês S. Albuquerque; Filipa Marcelo; Juan L. Asensio; Gonçalo J. L. Ber...; Hiren J. Joshi; Roberto Fiammengo; Ola Blixt; Ramón Hurtado-Gue...; Francisco Corzana
• Keywords: 0301 basic medicine; glycopeptides, mucin-1, antibodies; Glycosylation; Protein Conformation; Mucin-1; Glycopeptides; Antibodies, Monoclonal; Antineoplastic Agents; Hydrogen Bonding; Molecular Dynamics Simulation; Cancer Vaccines; Peptide Fragments; 3. Good health; Structure-Activity Relationship; 03 medical and health sciences; Lectins; Humans; Drug Screening Assays, Antitumor

The molecular basis of an anti-MUC1 antibody that recognizes the entire GalNAc unit as a primary epitope is disclosed.