Toxicity and chemical transformation of silver nanoparticles in A549 lung cells: dose-rate-dependent genotoxic impact

• DOI: 10.1039/d0en00533a
• Publication Date: 2021-02-26T08:53:35Z
• Authors: Laure Bobyk; Adeline Tarantini; David Beal; Giulia Veronesi; Isabelle Kieffer; Sylvie Motellier; Eugenia Valsami-J...; Iseult Lynch; Pierre-Henri Jouneau; Karin Pernet-Gallay; Catherine Aude-Ga...; Sylvie Sauvaigo; Thierry Douki; Thierry Rabilloud; Marie Carriere
• Keywords: Silver nanoparticle; Human lung

Acute exposure of A549 cells to Ag-NPs induces stronger effects on DNA integrity, ROS level, cell metabolism and cycle than repeated exposure. dissolves in both conditions Ag ions recombine with thiolated proteins.