Polyphenol from millet bran increases the sensitivity of colorectal cancer cells to oxaliplatin by blocking the ganglioside GM3 catabolism

• DOI: 10.1039/d0fo02232b
• Publication Date: 2020-11-20T07:23:41Z
• Authors: Xiaoli Zhang; Shuhua Shan; Jiangying Shi; Hanqing Li; Zhuoyu Li
• Keywords: Catabolism; Blocking (statistics)

The study implies that bound polyphenol from millet bran dramatically prevents ganglioside GM3 catabolism followed by the suppression of P-gp, which eventually reverse drug-resistance in colorectal cancer cells to oxaliplatin.