Discovery of novel JAK2 and EGFR inhibitors from a series of thiazole-based chalcone derivatives

• DOI: 10.1039/d0md00436g
• Publication Date: 2021-02-26T10:24:13Z
• Authors: Kamonpan Sanachai; Thitinan Aiebchun; Panupong Mahalapbutr; Supaphorn Seetaha; Lueacha Tabtimmai; Phornphimon Maitarad; Iakovos Xenikakis; Athina Geronikaki; Kiattawee Choowon...; Thanyada Rungrotm...
• Keywords: 0303 health sciences; 03 medical and health sciences; 3. Good health

The Janus kinase (JAK) and epidermal growth factor receptor (EGFR) have been considered as potential targets for cancer therapy due to their role in regulating proliferation and survival of cancer cells.