Design, synthesis and biological evaluation of a halogenated phenazine-erythromycin conjugate prodrug for antibacterial applications

• DOI: 10.1039/d0ob02428g
• Publication Date: 2021-01-18T15:45:09Z
• Authors: Hongfen Yang; Ke Liu; Shouguang Jin; Robert W. Huigens...
• Keywords: Phenazine; Conjugate; Enterococcus faecium; Enterococcus faecalis

We report the synthesis and initial biological assessment of a halogenated phenazine–erythromycin conjugate prodrug <bold>5</bold> aimed to treat bacterial infections.