Iodine-mediated formal [3 + 2] annulation for synthesis of furocoumarin from oxime esters

• DOI: 10.1039/d0ra07566c
• Publication Date: 2020-12-17T04:19:18Z
• Authors: Quyen T. Pham; Phong Q. Le; Ha V. Dang; Hiep Q. Ha; Huong T. D. Nguyen; Thanh Truong; Tri Minh Le
• Keywords: Furocoumarins; Furocoumarins; Annulation

A novel synthesis of furocoumarins was developed by a reaction between oxime esters and 4-hydroxycoumarins. The proposed to undergo radical mechanism mediated iodine, cheap common laboratory reagent. Mechanistic studies showed the key for successful transformation presence α-iodoimine intermediate which facilitated ring-closing step. conditions produced good functional group tolerance with wide range high-profile furocoumarin product. potential this strategy be applied in other syntheses heterocyclic compounds is highly achievable.