Biomimetic hydrogen-bonding cascade for chemical activation: telling a nucleophile from a base

• DOI: 10.1039/d0sc05067a
• Publication Date: 2020-11-02T08:26:08Z
• Authors: Hyunchang Park; Dongwhan Lee
• Keywords: Chemistry; 01 natural sciences; 0104 chemical sciences

Biomimetic cascade hydrogen bonds promote covalent capture of a nucleophile by polarizing the electrophilic reaction site, while suppressing non-productive acid–base chemistry as the competing reaction pathway.