Iron-catalyzed stereoselective haloamidation of amide-tethered alkynes

• DOI: 10.1039/d1cc00870f
• Publication Date: 2021-03-26T06:33:38Z
• Authors: Jin-Biao Liu; Miaofeng Ren; Xiaojing Lai; Guanyinsheng Qiu
• Keywords: Nitrene; Metalation; Alkyne; Amide

In this work, by using<italic>N</italic>-methoxybenzamides as efficient acyl nitrene precursors, an iron-catalyzed nitrene/alkyne metalation-based chloramidation is reported for the synthesis of isoindol-5-ones.