Probing serum N-glycan patterns for rapid and precise detection of Crohn's disease

• DOI: 10.1039/d1cc04699c
• Publication Date: 2021-10-07T13:24:43Z
• Authors: Yonglei Wu; Yijie Chen; Haolin Chen; Chenjie Yang; Xizhong Shen; Chunhui Deng; Nianrong Sun; Hao Wu
• Keywords: Adult; Male; 0303 health sciences; Glycosylation; Adolescent; Biosensing Techniques; Middle Aged; 3. Good health; 03 medical and health sciences; Crohn Disease; Polysaccharides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Humans; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Female; Child; Aged

Serum N-glycan patterns from 50 Crohn‘s disease (CD) patients and 50 healthy controls were acquired by a carbon matrix-based platform. According to statistical analysis, eight specific N-glycans revealed remarkable performance for CD diagnosis.