A hydrogel with supramolecular surface functionalization for cancer cell capture and multicellular spheroid growth and release

• DOI: 10.1039/d1cc05846k
• Publication Date: 2021-12-08T17:41:02Z
• Authors: Yuting Wen; Nana Nyarko Mensah; Xia Song; Jingling Zhu; Wui Siew Tan; Xinwei Chen; Jun Li
• Keywords: Spheroid; Surface Modification; Multicellular organism; Viability assay; Morphology

A hydrogel scaffold with a non-fouling but specific cancer cell-adhesive surface was fabricated through modification using β-cyclodextrin-based host-guest chemistry. Interestingly, the not only selectively captured cells, also grew cells into multicellular spheroids. The spheroids could be released without damaging cell viability replacing host moieties on scaffold, and showed no changes in size or morphology.