Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization

• DOI: 10.1039/d1cc06480k
• Publication Date: 2022-01-12T14:12:28Z
• Authors: Chenfei Wang; Xiaobei Huang; Litao Sun; Qiuxia Li; Zhili Li; Haiyang Yong; Delu Che; Cong Yan; Songmei Geng; Wenxin Wang; Dezhong Zhou
• Keywords: Cationic polymerization; Michael reaction; Closure (psychology)

Topological structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior transfection efficiency safety profile compared to their linear counterparts.