Cognitive improvement effect of nervonic acid and essential fatty acids on rats ingestingAcer truncatum Bungeseed oil revealed by lipidomics approach

• DOI: 10.1039/d1fo03671h
• Publication Date: 2022-01-21T08:01:00Z
• Authors: Wangting Song; Ke Zhang; Teng Xue; Jiarui Han; Fangda Peng; Chunguang Ding; Feng Lin; Jiujun Li; Fat Tin Agassi Sze; Jianwen Gan; Xianyang Chen
• Keywords: 0301 basic medicine; 0303 health sciences; Fatty Acids, Essential; Acer; Lipid Metabolism; Diet; Rats; 3. Good health; Fatty Acids, Monounsaturated; Rats, Sprague-Dawley; Disease Models, Animal; Random Allocation; 03 medical and health sciences; Cognition; Animals; Plant Oils; Maze Learning

Acer truncatum Bunge seed oil (ASO) is rich in ω-9 (53.93%) and ω-6 (30.7%) fatty acids (FAs) characterized by 3-7% nervonic acid (NA, C24:1ω-9). Evidence suggests that FAs such as NA participate processes of cognitive improvement; however, their mechanism remains ambiguous. In this study, we investigated the effect ASO on rat memory change lipid profiling underlying metabolism. After was administrated to rats for one, three seven days, capacity learning significantly increased via MWM test. Lipid showed alterations a wide range metabolic features after rats, which sphingolipids (SP) serum glycerophospholipids (GP) brain were regulated significantly. The changes synergetic effects NA, EA, OA DHA, where EA exhibited similar trends. enrichment analysis based KEGG indicated supplementation evoked pathways neurotrophin signaling, glycerophospholipid metabolism sphingolipid metabolism, are related cognition improvement. Among metabolites with different molecular forms, biomarkers C24:1ω-9 chains positive correlation others both SP GP. These results suggest synergistic conversion into each other may result enhanced ingesting oil.