On-chip perivascularnichesupporting stemness of patient-derived glioma cells in a serum-free, flowable culture

• DOI: 10.1039/d1lc00271f
• Publication Date: 2021-05-06T06:28:32Z
• Authors: Magda Gerigk; Harry Bulstrode; HaoTian Harvey Shi; Felix Tönisen; Camilla Cerutti; Gillian Morrison; David Rowitch; Yan Yan Shery Huang
• Keywords: Vascular Endothelial Growth Factor A; 0301 basic medicine; Brain Neoplasms; 610; Endothelial Cells; Glioma; 3. Good health; Chemistry; 03 medical and health sciences; Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life Sciences; Cell Line, Tumor; Neoplastic Stem Cells; Tumor Microenvironment; Humans; Glioblastoma; Cell Biology - Radboud University Medical Center

Glioblastoma multiforme is the most common and aggressive type of primary brain malignancy. Herein, a perivascularniche-on-a-chip is developed to study the interaction between patient-derived glioma stem cells and organotypical microvessels.