Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies

• DOI: 10.1039/d1lc01161h
• Publication Date: 2022-01-25T16:55:09Z
• Authors: Luca Docci; Nicolò Milani; Thomas Ramp; Andrea A. Romeo; Patricio Godoy; Daniela Ortiz Fra...; Stephan Krähenbühl; Michael Gertz; Aleksandra Galetin; Neil Parrott; Stephen Fowler
• Keywords: 0301 basic medicine; 03 medical and health sciences; Diclofenac; Cytochrome P-450 Enzyme System; Liver; Metabolic Clearance Rate; Lab-On-A-Chip Devices; Hepatocytes; Animals; Glucuronosyltransferase; Models, Biological

Microphysiological systems (MPS) are complex and more physiologically realistic cellular in vitro tools that aim to provide relevant human data for quantitative prediction of clinical pharmacokinetics while also reducing the need animal testing.