Enantioselective decarboxylative Mannich reaction of β-keto acids with C-alkynyl N-Boc N,O-acetals: access to chiral β-keto propargylamines

• DOI: 10.1039/d1ob01555a
• Publication Date: 2021-09-14T00:21:13Z
• Authors: Cong-Cong Zhang; Li-Jun Chen; Bao-Chun Shen; Hui-Ding Xie; Wei Li; Zhong-Wen Sun
• Keywords: Mannich reaction

The first asymmetric Mannich reaction of C -alkynyl N -Boc , O -acetals with β-ketoacids has been developed to access chiral β-keto propargylamines.