Cooperative stabilisation of 14-3-3σ protein–protein interactions via covalent protein modification

• DOI: 10.1039/d1sc02120f
• Publication Date: 2021-09-06T18:41:52Z
• Authors: Marta Falcicchio; Jake A. Ward; Sara Y. Chothia; Jaswir Basran; Alisha Mohindra; Salvador Macip; Pietro Roversi; Richard G. Doveston
• Keywords: 0301 basic medicine; Chemistry; 03 medical and health sciences; interaction; 612; stabilisation; 14-3-3; proteins; 3. Good health

The aminothiol WR-1065 covalently modifies 14-3-3σ to stabilse its interactions with p53 and ERα. It enhances the effect of fusicoccin A via a cooperative mechanism that leads to 14-3-3 partner-protein specific activty against cancer cells.