Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury

• DOI: 10.1039/d1sc04825b
• Publication Date: 2021-10-20T18:27:53Z
• Authors: Yong Zhang; Xueqian Chen; Qing Yuan; Yongning Bian; Mingrui Li; Yaling Wang; Xueyun Gao; Dongdong Su
• Keywords: Chemistry; 01 natural sciences; 0104 chemical sciences; 3. Good health

We rationally designed a leucine aminopeptidase (LAP) activated fluorogenic probe hCy-CA-LAP with high hepatocyte-targeting ability for accurate and sensitive imaging of DILI.