Selective non-enzymatic uric acid sensing in the presence of dopamine: electropolymerized poly-pyrrole modified with a reduced graphene oxide/PEDOT:PSS composite

• DOI: 10.1039/d2an01463g
• Publication Date: 2022-11-01T09:54:19Z
• Authors: Budi Riza Putra; Ulfiatun Nisa; Rudi Heryanto; Munawar Khalil; Fitri Khoerunnisa; Aga Ridhova; Yudi Nugraha Thaha; Frank Marken; Wulan Tri Wahyuni
• Keywords: Electrochemical gas sensor

A highly selective electrochemical sensor based on a molecularly imprinted polymer (MIP) to be developed for uric acid detection in the presence of dopamine as an interference molecule was demonstrated this study. This non-enzymatic by electropolymerizing poly-pyrrole onto composite electrochemically reduced graphene oxide (ErGO) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) glassy carbon electrode (GCE) give MIP/ErGO/PEDOT:PSS electrodes. The structural properties, surface morphology, interface fabricated then characterized using infrared spectroscopy, scanning electron microscopy, atomic force impedance spectroscopy. (MIP/ErGO/PEDOT:PSS modified GCE) also showed excellent analytical performance at optimum ratio monomer/template concentration optimized electropolymerization conditions, example low range 0.1-100 μM with limit 0.05 towards dopamine. Furthermore, exhibited good reproducibility stability measurements 5 consecutive days. In addition, demonstrates several interfering species such dopamine, urea, glucose, magnesium ions, ascorbic acid. ultimately satisfactory measurement samples human urine is expected used early-stage disease diagnosis.