pH-Responsive hyaluronic acid-enveloped ZIF-8 nanoparticles for anti-atherosclerosis therapy

• DOI: 10.1039/d2bm00603k
• Publication Date: 2022-07-13T09:40:47Z
• Authors: Essam Abdo Mohamm...; Shuai Wu; Yuan Zhong; Meng Yan; Li Zhu; Bibo Li; Yi Wang; Wei Wu; Guixue Wang
• Keywords: Mice; Drug Delivery Systems; 0103 physical sciences; Zeolites; Animals; Nanoparticles; Hyaluronic Acid; Hydrogen-Ion Concentration; 01 natural sciences; 3. Good health

A ZIF-8 nanoplatform decorated with HA has been developed to selectively deliver a drug into atherosclerotic plaques, and subsequently enhance local cargo release under acid stimuli for efficient safe anti-atherosclerosis therapy.