Carrier-free nanomedicine for enhanced photodynamic tumor therapy through glutathione S-transferase inhibition

• DOI: 10.1039/d2cc00235c
• Publication Date: 2022-02-24T07:01:26Z
• Authors: Xinyu Li; Renjiang Kong; Yanmei Li; Jiaqi Huang; Xiang Zhou; Shiying Li; Hong Cheng
• Keywords: 0301 basic medicine; Oxidative Stress; 03 medical and health sciences; Nanomedicine; Photosensitizing Agents; Porphyrins; Photochemotherapy; Neoplasms; Glutathione Transferase; 3. Good health

A chlorine e6 and coniferyl ferulate-based self-delivery nanomedicine is developed to inhibit intracellular glutathione S-transferase (GST) and enhance the photodynamic therapy (PDT)-mediated oxidative damage on tumor cells.