Tethered photocatalyst-directed palladium-catalysed C–H allenylation of N-aryl tetrahydroisoquinolines

• DOI: 10.1039/d2cc01064j
• Publication Date: 2022-03-09T22:41:06Z
• Authors: Mingfeng Li; Xiu Li Chia; Ye Zhu
• Keywords: Photoredox catalysis

Harnessing radical intermediates in regioselective reactions presents a substantial challenge. Here, we report novel control strategy through engineering covalently tethered transition metal-photocatalysts that conjoin Pd-phosphine and Ru/Ir photoredox units. This allows us to override the innate regioselectivity of Pd-catalysed C-H allenylation N-aryl tetrahydroisoquinolines.