Elucidating the coordination chemistry of the radium ion for targeted alpha therapy

• DOI: 10.1039/d2cc03156f
• Publication Date: 2022-08-19T08:19:39Z
• Authors: Alexander S. Ivanov; Megan E. Simms; Vyacheslav S. Bry...; Paul D. Benny; Justin R. Griswold; Laetitia H. Delmau; Nikki A. Thiele
• Keywords: Thermodynamics; 01 natural sciences; Chelating Agents; Radium; 3. Good health; 0104 chemical sciences

To advance the chelation chemistry of the elusive radium ion for targeted radionuclide therapy applications, we report its complexation thermodynamics with the macrocyclic chelators macropa and DOTA.