Three metal complexes with a pyridyl Schiff base: cytotoxicity, migration and mechanism of apoptosis

• DOI: 10.1039/d2dt02413f
• Publication Date: 2022-09-08T11:01:53Z
• Authors: Feiya Zhou; Fangxin Gao; Qinghua Chang; Xianfeng Yang; Lili Liang
• Keywords: Pyridines; Antineoplastic Agents; Apoptosis; DNA; Ligands; 01 natural sciences; 0104 chemical sciences; Structure-Activity Relationship; Coordination Complexes; Cell Line, Tumor; Cisplatin; Reactive Oxygen Species; Schiff Bases; Cadmium; Cell Proliferation

Three metal complexes were synthesized with a pyridyl Schiff ligand. 2 had the best antiproliferative activity against SMMC-7721 cells and 3 had the best antiproliferative activity against MDA-MB-231 cells with single-digit IC50 values.