Corn peptides improved obesity-induced non-alcoholic fatty liver disease through relieving lipid metabolism, insulin resistance and oxidative stress

• DOI: 10.1039/d2fo00199c
• Publication Date: 2022-04-01T13:22:29Z
• Authors: Kang Wei; Yang Wei; Weidong Xu; Feng Lu; Haile Ma
• Keywords: Liver function

Non-alcoholic fatty liver disease (NAFLD) is increasingly threatening human health. The remarkable effects of corn peptides (CPs) as bioactive on protection have attracted much attention. Nevertheless, the specific effect CPs NAFLD remains unclear. present study was designed to investigate efficacy in prevention and auxiliary treatment high-fat diet (HFD)-induced SD rats, puerarin used positive control. rats were fed a establish rat model, LO2 cells treated with high concentration fructose simulate cell model. comprehensively examined terms body weight, function markers, serum biochemistry histology. Protein expression determined using western blot analysis. results animal experiments showed that could effectively inhibit rate weight gain, reduce blood lipid level index, enhance glucose tolerance. accumulation lipids reactive oxygen species (ROS). In addition, markedly tissue, further evidenced by reduced SREBP-1c non-tumour hepatic (LO2) cells. Meanwhile, increased SIRT1/PPAR-α Nrf2/HO-1 pathways under pretreatment indicated relieve fat-induced injury, regulate insulin sensitivity, production ROS. vivo vitro demonstrated provided potential for through reducing accumulation, alleviating resistance, inhibiting oxidative stress. This investigated biological activity laid theoretical basis development CP-based functional foods dietary supplements.