Kiwicha (Amaranthus caudatus L.) protein hydrolysates reduce intestinal inflammation by modulating the NLRP3 inflammasome pathway

• DOI: 10.1039/d2fo02177c
• Publication Date: 2022-10-10T06:20:55Z
• Authors: Alicia Martinez-L...; Fernando Rivero-Pino; Alvaro Villanueva; Rocio Toscano; Elena Grao-Cruces; Elvira Marquez-Pa...; Maria E. Martin; Sergio Montserrat...; Maria C. Millan-L...
• Keywords: Proinflammatory cytokine; Nutraceutical; Caco-2; Functional food

The increase in the world population along with new policies aimed at a more sustainable has led to need of searching for food sources, which are environmentally friendly, implying healthy and nutritious diets. This study explored biological activity two kiwicha (Amaranthus caudatus L.) protein hydrolysates obtained aid Bioprotease LA-660 regarding their anti-inflammatory response intestinal level, employing CACO-2 cell line. results showed that vitro administration these decreased expression proinflammatory cytokines, increased gene major components inflammasomes model. To best our knowledge, this is first involving evaluation model its ultrastructural characterization using scanning electron microscopy. We conclude Amaranthus valuable source active peptides take part as functional ingredients nutraceutical preparations.