Tumour associated vasculature-on-a-chip for the evaluation of microbubble-mediated delivery of targeted liposomes

• DOI: 10.1039/d2lc00963c
• Publication Date: 2023-02-06T14:01:41Z
• Authors: Matthew D. Bourn; Safoura Zahed Moh...; Georgia Mavria; Nicola Ingram; P. Louise Coletta; Stephen D. Evans; Sally A. Peyman
• Keywords: Delivery system

The vascular system is the primary route for delivery of therapeutic drugs throughout body and an important barrier at region disease interest, such as a solid tumour. development complex 3D tumour cultures has progressed significantly in recent years however, generation perfusable vascularised models still presents many challenges. This study microfluidic-based vasculature that can be induced to display properties tumour-associated blood vessels without direct incorporation cells. Conditioning healthy endothelial-fibroblast cell co-cultures with media taken from was found result formation disorganised, tortuous networks which characteristics consistent those vasculature. Integrin α