Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry

• DOI: 10.1039/d2md00453d
• Publication Date: 2023-02-22T16:53:41Z
• Authors: Ross P. Thomas; Emma K. Grant; Eleanor R. Dickinson; Francesca Zappacosta; Lee J. Edwards; Michael M. Hann; David House; Nicholas C. O. To...; Jacob T. Bush
• Keywords: Chemistry; 610; 540; 01 natural sciences; 0104 chemical sciences

We present a carboxylate-targeting reactive fragment screening platform using 2-aryl-5-carboxytetrazole (ACT) as the photoreactive functionality. This work will provide a simple accessible method to rapidly discover tool molecules to interrogate important biological targets.