Targeting cell surface glycans with lectin-coated fluorescent nanodiamonds

• DOI: 10.1039/d2na00036a
• Publication Date: 2022-02-07T09:21:45Z
• Authors: Mina Ghanimi Fard; Zahra Khabir; Philipp Reineck; Nicole M. Cordina; Hiroshi Abe; Takeshi Ohshima; Sagar Dalal; Brant C. Gibson; Nicolle H. Packer; Lindsay M. Parker
• Keywords: 570; Macromolecular and materials chemistry; Technology; Science & Technology; Multidisciplinary; Materials engineering; 01 natural sciences; 0104 chemical sciences; 3. Good health; Chemistry; Physical Sciences; Nanotechnology; Nanoscience & Nanotechnology

Nanodiamonds were coated in lectins to target glycan receptors on astrocytes, neurons and microglia. The uptake in each cell type was variable depending on their coating of Aleuria aurantia lectin, wheat germ agglutinin or tomato lectin.