Design, synthesis, biological evaluation and molecular modelling studies of oxoacetamide warhead containing indole-quinazolinone based novel hybrid analogues as potential pancreatic lipase inhibitors

• DOI: 10.1039/d2nj01210c
• Publication Date: 2022-05-16T07:01:25Z
• Authors: Prashant S. Auti; Arijit Nandi; Vijeta Kumari; Atish T. Paul
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

A novel series of indolyl oxoacetamide-quinazolinone hybrid analogues (9aa–9df) were designed, synthesized, and evaluated for their in vitro pancreatic lipase (PL) inhibitory potential that may lead to efficient anti-obesity agents.