Quantification of mechanical stimuli inducing nucleoplasmic translocation of YAP and its distribution mechanism using an AFM–dSTORM coupled technique

• DOI: 10.1039/d2nr03366f
• Publication Date: 2022-10-03T14:54:38Z
• Authors: Hongru Li; Yong Liu; Jinrui Zhang; Mingjun Cai; Ziran Cao; Jing Gao; Haijiao Xu; Lina Shao; Jiayin Sun; Yan Shi; Hongda Wang
• Keywords: Cell Nucleus; YAP-Signaling Proteins; 02 engineering and technology; 0210 nano-technology; Adaptor Proteins, Signal Transducing; Transcription Factors; Signal Transduction

The combination of AFM and dSTORM technologies provides precise in situ manipulation of cells and real-time monitoring of YAP in response to mechanical forces for nuclear translocation.