Carbene-catalyzed kinetic resolution of bispirooxindoles: selective lactam amidation and access to challenging chiral scaffolds

• DOI: 10.1039/d2qo01724e
• Publication Date: 2023-01-04T07:03:19Z
• Authors: Yiru Pu; Yi Zuo; Jie Ling; Meimei Li; Hui Huang; Chaozheng Zhang; Jirui Yang; Yun Deng; Maolin Wang; Jun Lu
• Keywords: 01 natural sciences; 0104 chemical sciences

Despite kinetic resolution (KR) via N-heterocyclic carbene (NHC)-catalyzed acylation minimizing any competitive racemic background reactions, the KR of NHC-activated lactam amidation is mostly uninvestigated.