Construction of multi-substituted pyrazoles via potassium carbonate-mediated [3 + 2] cycloaddition of in situ generated nitrile imines with cinnamic aldehydes

• DOI: 10.1039/d2ra00331g
• Publication Date: 2022-04-29T10:22:45Z
• Authors: Mei-Mei Li; Hui Huang; Wanrong Tian; Yiru Pu; Chaozheng Zhang; Jirui Yang; Qing Ren; Feiyan Tao; Yun Deng; Jun Lu
• Keywords: Chemistry; 01 natural sciences; 0104 chemical sciences

A highly efficient potassium carbonate-mediated [3 + 2] cycloaddition reaction of hydrazonoyl chlorides with cinnamic aldehydes to furnish multi-substituted pyrazoles under nontoxic and mild conditions has been developed.