A regio- and stereoselective Heck–Matsuda process for construction of γ-aryl allylsulfonyl fluorides

• DOI: 10.1039/d2ra03733e
• Publication Date: 2022-07-04T08:43:33Z
• Authors: Hao-Yong Qin; Houying Gui; Zai-Wei Zhang; Tao Shu; Hua-Li Qin
• Keywords: Heck Reaction

A highly efficient regio- and stereoselective Heck-Matsuda method was developed employing aryl diazoniums allylsulfonyl fluorides for the construction of a class novel γ-aryl in presence Pd(OAc)2 PPh3. The features excellent stereoselectivity (up to 100% E-selectivity), broad substrate scope mild reaction conditions. Further application fluoride SuFEx reactions achieved provide their corresponding sulfonates sulfonamides yields.