Molecularly imprinted polymers outperform lectin counterparts and enable more precise cancer diagnosis

• DOI: 10.1039/d2sc01093c
• Publication Date: 2022-03-17T13:21:31Z
• Authors: Jilei Pang; Pengfei Li; Hui He; Shuxin Xu; Zhen Liu
• Keywords: Molecularly imprinted polymer

Accurately analysing the particular glycosylation status of protein biomarkers is significant importance in precise, early diagnosis cancer. Existing methods mainly rely on use antibodies and lectins. However, due to macroscopic microscopic heterogeneity glycans, precise analysis still remains a challenge. Molecularly imprinted polymers (MIPs), as synthetic alternative or lectins, may provide new solutions but have not yet been explored. Herein, we report an appealing strategy called triple MIP-based plasmonic immunosandwich assay (triMIP-PISA) for cancer terms relative expression glycoprotein biomarkers. As proof principle, alpha fetoprotein (AFP), which has used clinical biomarker detection hepatocellular carcinoma (HCC), well its