A senolysis-based theragnostic prodrug strategy towards chronic renal failure

• DOI: 10.1039/d2sc03525a
• Publication Date: 2022-09-26T13:21:32Z
• Authors: Yihe Song; Xinming Li; Donglei Shi; Tianyue Sun; Wenwen Liu; Xiaokang Li; Sicong Qiao; Xin Chen; Yuan Guo; Jian Li
• Keywords: Chronic renal failure

Here, we report a senescence-associated β-galactosidase activatable theragnostic prodrug to pertinently treat chronic renal failure (CRF) in mice with the aid of fluorescence-guided senolysis, providing creative molecular approach CRF therapy.