Ligand-free Pd-catalyzed double Heck reaction of N-(o-bromoaryl)acrylamides with α-F/CF3-acrylates

• DOI: 10.1039/d3cc01740k
• Publication Date: 2023-06-13T02:01:15Z
• Authors: Ruchi Sharma; Swati Jain; Naveen Sihag; M. Ramu Yadav

A ligand-free Pd-catalyzed double-Heck cascade between N-(o-bromoaryl)acrylamide and α-fluorinated acrylates have enabled biologically important mono-fluoro/trifluoromethyl groups attached oxindole moieties in good yields.