Theoretical analysis of divalent cation effects on aptamer recognition of neurotransmitter targets

• DOI: 10.1039/d3cc04334g
• Publication Date: 2023-11-17T07:41:49Z
• Authors: Ali Douaki; Annina Stuber; Julian Hengsteler; Dmitry Momotenko; David M. Rogers; Walter Rocchia; Jonathan D. Hirst; Nako Nakatsuka; Denis Garoli
• Keywords: Serotonin; Condensed Matter - Mesoscale and Nanoscale Physics; Cations, Divalent; Dopamine; Circular dichroism spectroscopy; FOS: Physical sciences; Physics - Applied Physics; Biosensing Techniques; Applied Physics (physics.app-ph); DNA aptamer; Aptamers, Nucleotide; Molecular Dynamics Simulation; Molecular dynamic simulations; Chemistry; Field-effect transistor; Mesoscale and Nanoscale Physics (cond-mat.mes-hall); Biosensor

This work demonstrates how molecular dynamics simulations can be a powerful tool to understand the behaviours of aptamer-based sensors.