Implementation of micelle-enabled C(sp2)–C(sp3) cross-electrophile coupling in pharmaceutical synthesis

• DOI: 10.1039/d3cc05916b
• Publication Date: 2024-01-22T07:05:14Z
• Authors: Bin Wu; Ning Ye; Kangming Zhao; Min Shi; Jiayu Liao; Jing Zhang; Wei Chen; Xianzhong Li; Yufeng Han; Margery Cortes-Cl...; Morgan Louis Regnier; Michael Parmentier; Christian Mathes; Florian Rampf; Fabrice Gallou
• Keywords: Aqueous medium; Dual role; Electrophilic substitution

A sustainable C(sp 2 )–C(sp 3 ) cross-electrophile coupling was developed between readily available 5-bromophthalide and 1-benzyl-4-iodopiperidine under micellar conditions, leading to a key intermediate of one our development compounds.