Implementation of micelle-enabled C(sp2)–C(sp3) cross-electrophile coupling in pharmaceutical synthesis

Solvents Water Micelles Catalysis 0104 chemical sciences
DOI: 10.1039/d3cc05916b Publication Date: 2024-01-22T07:05:14Z
ABSTRACT
A sustainable C(sp2)–C(sp3) cross-electrophile coupling was developed between readily available 5-bromophthalide and 1-benzyl-4-iodopiperidine under micellar conditions, leading to a key intermediate of one of our development compounds.
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