Rivaroxaban eutectics with improved solubility, dissolution rates, bioavailability and stability

• DOI: 10.1039/d3ce00261f
• Publication Date: 2023-04-24T08:02:35Z
• Authors: Parth S. Shaligram; Christy P. George; Himanshu Sharma; Kakasaheb R. Mahadik; Sharvil Patil; Kumar Vanka; S. Arulmozhi; Rajesh G. Gonnade

Six acidic coformers were used to prepare eutectics of rivaroxaban (RXB), a factor Xa inhibitor. The displayed improved solubility, dissolution rate, and bioavailability RXB, without compromising on its stability.