Uncovering the anti-inflammatory mechanisms of phenolic-enriched maple syrup extract in lipopolysaccharide-induced peritonitis in mice: insights from data-independent acquisition proteomics analysis

• DOI: 10.1039/d3fo01386c
• Publication Date: 2023-06-27T11:31:08Z
• Authors: Tess Puopolo; Huifang Li; Hang Ma; Joseph M. Schrader; Chang Liu; Navindra P. Seeram
• Keywords: Lipopolysaccharides; Proteomics; Mice; Phenols; Plant Extracts; Anti-Inflammatory Agents; Animals; Cytokines; Acer; Peritonitis; 3. Good health

Our group has previously reported on the phytochemical composition and biological activities of a phenolic-enriched maple syrup extract (MSX), which showed promising anti-inflammatory effects in several disease models including diabetes Alzheimer's disease. However, efficacious doses MSX its molecular targets involved are not fully elucidated. Herein, efficacy peritonitis mouse model was evaluated dose-finding study underlying mechanisms were explored using data-independent acquisition (DIA) proteomics assay. (at 15, 30 60 mg kg