Dietary Lactobacillus rhamnosus GG extracellular vesicles enhance antiprogrammed cell death 1 (anti-PD-1) immunotherapy efficacy against colorectal cancer

• DOI: 10.1039/d3fo02018e
• Publication Date: 2023-10-04T14:12:44Z
• Authors: Shun Lu; Jing Xu; Zihao Zhao; Yuheng Guo; Hanwen Zhang; Peter W. Jurutka; Dechun Huang; Chongjiang Cao; Shujie Cheng
• Keywords: Mice; Extracellular Vesicles; Cell Death; Lacticaseibacillus rhamnosus; Probiotics; Animals; Immunotherapy; CD8-Positive T-Lymphocytes; Colorectal Neoplasms

Dietary Lactobacillus rhamnosus GG extracellular vesicles (LGG-EV) synergistically enhanced anti-PD-1 immunotherapy efficacy against colorectal cancer. It was associated with improved tumor immunosuppressive environment, the abundance of beneficial bacteria and elevated specific serum metabolites.